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DiacetylMorphine dependence (HD) is a chronic relapsing brain disorder that is defined by a compulsion to seek and use heroin, and a loss of control in limiting intake. Buy DiacetylMorphine Online, Cheap DiacetylMorphine 15mg
The prescription of diacetylmorphine (heroin) itself for maintenance has become an established treatment in several European countries. However, the neurobiological effects of diacetylmorphine (DAM) on brain function and stress response have not been studied so far.
Imaging the acute effects of DAM administration during stress stimuli would elucidate the neurocircuitry and neurobiology of substance use in patients with HD.
The investigators expect that DAM attenuates the engagement of brain regions involved in response inhibition (prefrontal and anterior cingulate cortex), emotional processing (amygdala), and working memory (frontal and mediotemporal cortex). Additionally, we hypothesize that DAM reduces stress response (cortisol, heart rate, skin conductance) to emotional and cognitive stimuli.
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The heroin-dependent patients will administer either their individual dose or prescribed DAM dose of saline through an indwelling intravenous line. Afterward, they will complete four experimental paradigms testing response inhibition, emotional processing, and working memory while brain responses are measured with fMRI. Before and after the fMRI investigation cortisol samples, DAM blood levels, neurophysiological and psychological stress parameters, such as skin conductance, heart rate, anxiety, anger, and heroin craving will be measured.
Morphine, Diamorphine, and many other opioids produce analgesia. They behave like agonists on a complex group of receptors on which endogenous peptides called endorphins normally act.
Besides analgesia, diamorphine produces drowsiness, euphoria, and also a feeling of detachment. Negative effects include firstly respiratory depression, secondly, nausea and vomiting. In addition, decreased motility of the gastrointestinal tract, suppression of the cough reflex, and also hypothermia.
The expected value of the proposed project:
DAM effects on brain function and stress will advance our understanding of the mechanisms underlying HD. It is the first neuroimaging study investigating the neural basis of HD after intravenous DAM administration in humans. Buy DiacetylMorphine Online, Cheap DiacetylMorphine 15mg.
Pharmacology Buy DiacetylMorphine Online, Cheap DiacetylMorphine 15mg.
Diamorphine, like morphine and many other opioids, produces analgesia. It behaves as an agonist at a complex group of receptors that are normally acted upon by endogenous peptides known as endorphins.
Apart from analgesia, diamorphine produces drowsiness, euphoria, and a sense of detachment. Negative effects include respiratory depression, nausea, and vomiting, decreased motility in the gastrointestinal tract, suppression of the cough reflex, and hypothermia.
Tolerance and physical dependence occur on repeated use. Cessation of use intolerant subjects leads to characteristic withdrawal symptoms. Buy DiacetylMorphine Online, Cheap DiacetylMorphine 15mg.
Subjective effects following injection are known as ‘the rush’ and are associated with feelings of warmth and pleasure, followed by a longer period of sedation.
Diamorphine is 2–3 times more potent than morphine.
The estimated minimum lethal dose is 200 mg, but addicts may be able to tolerate ten times as much. Buy DiacetylMorphine Online, Cheap DiacetylMorphine 15mg.
Mode of use
Heroin from south-west Asia may be ‘smoked’ by heating the solid on a metal foil above a small flame and inhaling the vapor.
Those intending to inject this form of heroin must first solubilize it with, for example, citric acid or ascorbic acid.
Heroin from south-east Asia is suitable for direct injection of a solution. A typical dose is 100 mg at street level purity.
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